Raimund Hirschberg, M.D.

Selected Original Publications

· Hirschberg R, JD Kopple. Evidence that Insulin-like growth factor I increases renal plasma flow and GFR in fasted rats. J Clin Invest 83 (1989), 326-330

· Hirschberg R, Kopple J, Blantz R, Tucker B: Effects of recombinant human insulin-like growth factor I on glomerular dynamics in the rat. J Clin Invest 87 (1991), 1200-1206.

· Hirschberg R, Kopple J: The growth hromone - IGF-I axis and renal glomerular function. J Am Soc Nephrol 2 (1992), 1417-1422.

· Ding H, Kopple J, Cohen A, Hirschberg R: Recombinant human insulin-like growth factor I accelerates recovery and reduces catabolism in rats with ischemic acute renal failure. J Clin Invest 91 (1993), 2281-2287.

· Hirschberg R, Ding H, Wanner C: Effects of insulin-like growth factor I on phosphate transport in cultured proximal tubule cells. J Lab Clin Med 125 (1995), 428-434.

· Feld S, Hirschberg R, Artishevsky A, Nast C, Adler S: Insulin-like growth factor I induces mesangial proliferation and increases mRNA and secretion of collagen. Kidney Int 48 (1995), 45-51.

· Hirschberg R, Kaysen G: Insulin-like growth factor-I and its binding proteins in the experimental nephrotic syndrome. Endocrinology 136 (1995), 1565-1571.

· Ding H, Gao X, Hirschberg R, Vadgama J, Kopple J: Effects of insulin-like growthfactor I on protein synthesis and degradation in skeletal muscle of rats with chronic renal failure: Evidence for a postreceptor defect. J Clin Invest 97 (1996), 1064-1075.

· Hirschberg R: Bioactivity of glomerular ultrafiltrate during heavy proteinuria may contribute to renal tubulo-interstitial lesions: Evidence for a role of insulin-like growth factor I. J Clin Invest 98 (1996), 116-124.

· Feld S, Hirschberg R: Growth Hormone, the IGF-System and the Kidney. Endocr Rev 17 (1996), 423-480

· Bohe J, Ding H, Quing D, Yoon K, Hirschberg R, Kopple J: IGF-Binding Proteins, IGF-Binding Protein mRNA and IGF-I Receptor mRNA in Rats with Acute Renal Failure given IGF-I. Kidney Int 54 (1998), 1070-1082

· Hirschberg R, Ding H: Mechanisms of IGF-I-incuded accelerated recovery in experimental ischemic acute renal failure. Mineral Electrolyte Metab 24 (1998), 211-219.

· Hirschberg R, Kopple J, Lipsett P, Benjamin E, Minei J, Albertson T, Munger M, Metzler M, Zaloga G, Murray M, Lowry S, Conger J, McKeown W, O=Shea M, Baughman R, Wood K, Haupt M, Kaiser R, Simms H, Warnock D, Summer W, Hintz R, Myers B, Haenftling K, Capra W, Pike M, Guler H: Multicenter Clinical Trial of recombinant human insulin-like growth factor I in patients with acute renal failure. Kidney Int 55 (1999), 2423-2432.

· Wang S, LaPage J, Hirschberg R: Glomerular ultrafiltration and apical tubular action of IGF-I, TGF-β and HGF in the nephrotic syndrome. Kidney Int 56(1999), 1247-1251.

· Wang S, LaPage J, Hirschberg R: Glomerular ultrafiltration of IGF-I may contribute to increased renal sodium retention in diabetic nephropathy. J Lab Clin Med 134 (1999), 154-160.

· Wang S, Hirschberg R: Tubular epithelial cell activation and interstitial fibrosis in the nephrotic syndrome - what is the role of glomerular ultrafiltration of growth factors? Editorial Comment, Nephrol Dial Transpl 14:2072-2074, 1999.

· Wang S, LaPage J, Hirschberg R: Proteinuria and Progression of Chronic Renal Disease. Kidney Blood Press Res 23:167-169, 2000.

· Wang S, LaPage J, Hirschberg R: Role of glomerular ultrafiltration of growth factors in progressive interstitial fibrosis in diabetic nephropathy. Kidney Int 57 (2000), 1002-1014.

· Wang S, LaPage J, Hirschberg R: Growth factor ultrafiltration in glomerular proteinuria causes tubular cell transformation. Am J Physiol 278 (2000), F554-F560.

· Wang S, DeNichilo M, Brubaker C, Hirschberg R: Connective tissue growth factor in tubulo-interstitial injury of diabetic nephropathy. Kidney Int 60 (2001), 96-105.

· Wang S, LaPage J, Hirschberg R: Loss of bone morphogenetic protein-7 in diabetic nephropathy. J Am Soc Nephrol 12:2392-2399, 2001.

· Wang S, Hirschberg R: BMP7 antagonizes TGF-beta – dependent fibrogenesis in mesangial cells. Am J Physiol Renal Physiol 284:F1006-F1013, 2003.

· Wang S, Hirschberg R: BMP7 signals opposing TGFβ in mesangial cells. J Biol Chem 279:23200-23206, 2004.

· Hirschberg R: What Benjamin Babington, William Osler, Frederick Weber, and Henri Rendu did not know. Cardiovasc Res 68:180-182, 2005.

· Hirschberg R: Protein Ultrafiltration and interstitial fibrogenesis. Curr Opin Nephrol Hypertens 14:43-52, 2005.

· Hirschberg R: Wound healing in the kidney: Complex interactions in renal interstitial fibrogenesis. J Am Soc Nephrol 16: 9-11, 2005.

· Wang S, Wilkes M, Leof E, Hirschberg R: Imatinib mesylate blocks a non-smad TGFβ pathway and reduces renal fibrogenesis in-vivo. FASEB J 19: 1-11. 2005.

· Wang S, de Caestecker M, Kopp J, Mitu G, LaPage J, Hirschberg R: Renal bone morphogenetic protein-7 protects against diabetic nephropathy. J Am Soc Nephrol 17:2504-2512, 2006. Hirschberg R: Proteinuria and Interstitial Disease in Diabetic Nephropathy,. In: Mogensen CE, Cortes P (Edits), 'Diabetic Nephropathy', Humana Press. 2007.

· Mitu G, Wang S, Hirschberg R: BMP7 is an autocrine podocyte survival factor and rescues podocytes from diabetic injury. Am J Physiol Renal Physiol 293:F1641-F1648, 2007.

· Hirschberg R, Wang S, Mitu G: Functional Symbiosis between Endothelium and Epithelial Cells in Glomeruli. Cell Tissue Res 331:485-493, 2008.

· Mitu G, Hirschberg R: BMP7 in Chronic Kidney Disease. Front Biosci 13:4726-4739, 2008.

· Wang S, Mitu G, Hirschberg R: Osmotic polyuria: An overlooked mechanism in diabetic nephropathy. Nephrol Dial Transpl 23:2167-2172, 2008.